Case of the Month #28: Opioid-induced hyperalgesia by Dr Nofil Mulla

Published: 30/05/2023

Further Reading

  1. Treister R, Eisenberg E, Lawental E, Pud D. Is opioid-induced hyperalgesia reversible? A study on active and former opioid addicts and  drug naive controls. J. Opioid Manag. 8(6), 343–349 (2012). 
  2. Samuelsen PJ, Nielsen CS, Wilsgaard T, Stubhaug A, Svendsen K, Eggen AE. Pain sensitivity and analgesic use among 10,486 adults: the Tromso study. BMC Pharmacol. Toxicol. 18(1), 45 (2017).
  3. Sorensen J, Sjogren P. The clinical relevance of opioid-induced hyperalgesia remains unresolved. Ugeskr. Laeger 173(13), 965–968 (2011). 
  4. Khomula EV, Araldi D, Levine JD. In vitro nociceptor neuroplasticity associated with in vivo opioid-induced hyperalgesia. J. Neurosci. 39(36), 7061–7073 (2019). 
  5. Roeckel LA, Utard V, Reiss D et al. Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide. Sci. Rep. 7(1), 10406 (2017). 
  6. Higgins C, Smith BH, Matthews K. Evidence of opioid-induced hyperalgesia in clinical populations after chronic opioid exposure: a systematic review and meta-analysis. Br. J. Anaesth. 122(6), e114–e126 (2019). 
  7. Virani F, Miller M, Gilmour J. Opioid-induced hyperalgesia from alfentanil. BMJ Support Palliat. Care 10(3), 310–311 (2020). 
  8. Fletcher D, Martinez V. Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis. Br. J. Anaesth. 112(6), 991–1004 (2014). 
  9. Van Gulik L, Ahlers SJ, Van De Garde EM et al. Remifentanil during cardiac surgery is associated with chronic thoracic pain 1 yr after sternotomy. Br. J. Anaesth. 109(4), 616–622 (2012). 
  10. Salengros JC, Huybrechts I, Ducart A et al. Different anesthetic techniques associated with different incidences of chronic post-thoracotomy pain: low-dose remifentanil plus presurgical epidural analgesia is preferable to high-dose remifentanil with postsurgical epidural analgesia. J. Cardiothorac. Vasc. Anesth. 24(4), 608–616 (2010).